Xbp1 Pancreas

Endoplasmic Reticulum Stress In Immunity - Annual Reviews
Endoplasmic Reticulum Stress in Immunity Sarah E. Bettigole1,2 and Laurie H. Glimcher1 1Department of Medicine, Weill Cornell Medical College, New York, the exocrine pancreas. Similarly, loss of Ern1, Xbp1,orEif2ak3 in the adult animal leads to sig- ... Read Document

Cancer Imaging The Unfolded Protein Response In Primary ...
Imaging the Unfolded Protein Response in Primary Tumors Reveals Microenvironments with Metabolic Variations that Predict Tumor Growth Michael T. Spiotto1, XBP1-luciferase (XBP1-luc) activity as a marker for ER detectable in the pancreas and liver ... Fetch Here

Supporting Information - PNAS
Supporting Information Iwawaki et al. 10.1073/pnas.0903775106 Fig.S1. Quantitative PCR analysis of endogenous XBP1 in liver, pancreas, and kidney tissues of ERAI-LUC mice. XBP1-deficient mice survived until E12.5, ... Get Document

Establishing The Role Of The Pancreatic Transcription Factor ...
Establishing The Role Of The Pancreatic Transcription Factor Mist1 In Xbp1-Mediated Maintenance Of Pancreatic Acinar Cell Homeostasis David Alan Hess Additionally, cells still expressing XBP1 in the pancreas were characterized following ER stress-induced organ damage as a means to ... Retrieve Content

NIH Public Access Jeff Ishibashi Barbara Damsz Ann-Hwee Lee ...
Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice David A. Hess*,1, Sean E. Humphrey*,1, Jeff Ishibashi1, Barbara Damsz1, Ann-Hwee Lee2, ... Get Document

XBP1 - Pancreapedia
3 exocrine pancreas. To more thoroughly determine the role of XBP1 in the pancreatic acinar cell Stephen Konieczny’s group crossed Xbp1flox (18) mice with Mist1- ... Retrieve Doc

BASIC—LIVER, PANCREAS, AND BILIARY TRACT
Pancreas of Xbp1/ mice. In these mice, protein levels of the XBP1 target PDI were significantly reduced by 18%, consistent with a partial Xbp1 deletion. No differences were found in levels of other ER stress regulators such as IRE1 and Grp78. ... Access Content

Page 1 Of 35 Diabetes
1 X-box binding protein 1 is essential for insulin regulation of pancreatic alpha cell function Running title: Role of XBP1 in pancreatic α-cells ... Read Content

Pancreatic Adaptive Responses In Alcohol Abuse: Role Of The ...
Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response Aurelia Lugea, (XBP1) mRNA resulting in genetic ablation of Xbp1 in pancreas and other tissues is ... Read More

A Modified UPR Stress Sensing System Reveals A Novel Tissue ...
ORIGINAL PAPER A modified UPR stress sensing system reveals a novel tissue distribution of IRE1/XBP1 activity during normal Drosophila development ... Content Retrieval

Xbp1 FDOFJDTPJ# TFEOB- Ü FUVCJSUTJE UPO P%
Pancreas, ERAD, UPR, XBP1 Submitted: 03/05/11 Revised: 03/14/11 Accepted: 03/23/11 Scheme depicting mechanisms regulating autophagic activity in pancreas of wild-type and XB p1-deficient mice fed ethanol-containing diets. FDOFJDTPJ# TFEOB- Ü ... Read More

Overview Of The Unfolded Response
Overview of the Unfolded Protein Response 13th International Myeloma Workshop 6 Pancreas Salivary gland XBP1 is highly expressed in secretory organs. 6 Role of XBP1 in development of secretory cells ... Fetch Doc

Supporting Information - PNAS
Supporting Information Lee et al. 10.1073/pnas.1105564108 SI Materials and Methods Generation of β-Cell-Specific XBP1 KO Mice. Pancreas sections of WT and Xbp1f/f;RIP-cre mice were double stained with insulin and glucagon antibodies. (Scale bar, 50 μm.) ... Content Retrieval

Supplemental Data Endoplasmic Reticulum Stress Plays A ...
Supplemental Data Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance Pancreas Histology and ER Stress in Peripheral Tissues of XBP1 s (rev) 5 – AGG CTT GGT GTA TAC ATG G ... View Doc

Adipocyte Cell 3D Model - YouTube
Adipocyte Cell 3D Model Jared Gay. Subscribe Subscribed Unsubscribe 0 0. Loading Loading Working Add to. Want to watch this again later? Sign in to add this video to a playlist. Sign in. Share More. Report. Need to report the video? ... View Video

Restoration Of The Unfolded Protein Response In Pancreatic β ...
Restoration of the Unfolded Protein Response in Pancreatic β Cells pancreas and increased survival, and XBP1 (X-box binding protein 1), in pancreatic β cells from T1D patients and two distinct mouse models of T1D. ... Get Doc

Alcohol Abuse, Endoplasmic Reticulum Stress And Pancreatitis
Abuse on the exocrine pancreas. Alcohol, ER Stress and the UPR Long-term feeding of ethanol alone causes minimal I n the pancreatic tissue of the XBP1-deficient animals receiving alcohol there was a seriously disorganized ul-trastructure with a decreased number of zymogen gran- ... Access Content

TCF3 - Wikipedia, The Free Encyclopedia
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. [1] [2 XBP1 (1.2) Basic helix-loop-helix : ATOH1; AhR; AHRR; ARNT; ASCL1; BHLH. 2; 3; 9; ARNTL. ARNTL; ARNTL2; CLOCK; EPAS1; FIGLA; HAND ... Read Article

What Are Cancer Cells?
What are Cancer Cells? By Lynne Eldridge MD. Lung Cancer Expert Share Pin Tweet Submit Stumble Post Share National Cancer Institute, Dr. Cecil Fox (photographer) Written or medically reviewed by a board-certified physician. ... Read Article

A Modified UPR Stress Sensing System Reveals A Novel Tissue ...
XBP1 stress sensing system allowed us to detect new IRE1/ XBP1 activities in the brain, gut, Malpighian tubules, and trachea of detected in the muscle, pancreas, brain, and heart only weeks after birth (Iwawaki et al. 2004). In ... View Full Source

Author Manuscript NIH Public Access 3, And Induced Pancreatic ...
Including pancreatic acinar cells.22 Although XBP1 actions vary between different cell types, genetic alterations of XBP1 are linked to several disorders including diabetes, IBD, ... Retrieve Doc

ISL1 - Wikipedia, The Free Encyclopedia
The validity of ISL1 as a marker for cardiac progenitor cells has been questioned since some groups have found no evidence that ISL1 cells serve as cardiac XBP1 (1.2) Basic helix-loop-helix : ATOH1; AhR; AHRR; ARNT; ASCL1; BHLH. 2; 3; 9; ARNTL. ARNTL; ARNTL2; CLOCK; EPAS1; FIGLA; HAND. 1; 2 ... Read Article

Pancreatic Stress And Regeneration - Gastroenterology
Gous for Xbp1, that have a normal pancreas as adults, were shown to be highly susceptible to alcoholic pancre-atitis, and sustain more severe damage than their wild-type counterpart, with increase of ER stress and apoptosis ... View Doc

Extensive Pancreas Regeneration Following Acinar-Specific ...
Extensive Pancreas Regeneration Following Acinar-Specific Disruption of Xbp1 in Mice DAVID A. HESS,* SEAN E. HUMPHREY,* JEFF ISHIBASHI,* BARBARA DAMSZ,* ANN–HWEE LEE,‡ ... Access Document